Novoprotein Assists in Nuerological Disease Study

Microglia are a type of cell located in the brain and spinal cord, and act as an active immune defense in the central nervous system. As researchers from the University of California wrote: “Microglia play critical roles in brain development, homeostasis, and neurological disorders”.

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University of California, Irvine – “Let there be light”

 

Their findings were published in Neuron, a scientific journal from http://www.cell.com, in their article named:
iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

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Neuron – Volume 94; Number 2 (April 19, 2017)

 

These scientists attempted to study their function in relationship to neurological diseases, such as Alzheimer’s, to provide important new insight into human neurological disease. Specifically, they report that microglial-like cells, iPSC-dervied microglia (iMGL), can be differentiated fromĀ induced pluripotent stem cellsĀ (iPSC).

During their studies, they used Novoprotein Recombinant Human CD200 to culture iMGLs in complete differentiation media. This was the final step in allowing differentiation of iHPCs to iMGLs, done after 25 days of microglial differentiation (35 days from iPSC)

From their studies, they were able to conclude links between genes expressed from iMGLs to Alzheimer’s Disease (AD), Amyotrophic Lateral Sclerosis (ALS), Huntington’s Disease (HD), Frontal Temporal Dementia (FTD), and Dementia with Lewy Bodies (DLB).

Perhaps information from this study will become invaluable for future studies into these neurological diseases. Novoprotein looks forward to the opportunity to assist again, and is proud of the scientific community and all its achievements; both current and future.